Roy-Byrne P, Radant A, Wingerson D, Cowley D S
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, USA.
Biol Psychiatry. 1995 Jul 15;38(2):92-7. doi: 10.1016/0006-3223(94)00225-R.
To provide information on test-retest reliability for seven oculomotor paradigms currently used in studies of schizophrenia and other neuropsychiatric conditions, we tested eight controls at four weekly intervals, twice in the morning (8-10 AM) and twice in the afternoon (3-5 PM). Intraclass correlation coefficients were significant (p < .05) for both AM and PM pairs of measures as well as for mean AM and PM pairs for closed-loop pursuit gain, open-loop pursuit gain (using velocity as the measure), saccadic frequency during pursuit and fixation, visually and nonvisually guided saccadic latency and velocity, antisaccadic latency, and premature reflexive saccades during the memory-guided saccade task. Acceleration as a measure of open-loop gain (for slower targets) and accuracy of saccades to a moving target were only reliable at PM testing time. Nonvisually guided saccadic accuracy and inappropriate reflexive saccades during the antisaccade task were not reliable, possibly due to the narrow range of values for these measures. Except for approximately 10% fewer saccades during pursuit and fixation in the morning, there were no consistent diurnal differences. These findings suggest that, in a small sample of subjects, most measures of oculomotor function are stable across time and may reflect underlying neurophysiologic traits.
为了提供目前在精神分裂症和其他神经精神疾病研究中使用的七种眼动范式的重测信度信息，我们对八名对照者进行了测试，每周测试一次，共四次，上午（上午8点至10点）测试两次，下午（下午3点至5点）测试两次。组内相关系数在上午和下午的测量对以及闭环追踪增益、开环追踪增益（以速度为测量指标）、追踪和注视期间的扫视频率、视觉和非视觉引导的扫视潜伏期和速度、反扫视潜伏期以及记忆引导扫视任务期间的过早反射性扫视的上午和下午平均测量对上均具有显著性（p < 0.05）。以加速度作为开环增益的测量指标（针对较慢目标）以及对移动目标的扫视准确性仅在下午测试时可靠。反扫视任务期间的非视觉引导扫视准确性和不适当的反射性扫视不可靠，可能是由于这些测量指标的值范围较窄。除了上午追踪和注视期间的扫视次数比下午少约10%外，没有一致的昼夜差异。这些发现表明，在一小部分受试者中，大多数眼动功能测量指标随时间稳定，可能反映了潜在的神经生理特征。
