Shaunak S, Orrell R, Henderson L, Kennard C
Division of Sensorimotor Systems, Imperial College School of Medicine, London, UK.
J Neurol. 1999 Jul;246(7):600-6. doi: 10.1007/s004150050411.
Reflexive saccades, remembered saccades, antisaccades, fixation and smooth pursuit were recorded in seven subjects with myotonic dystrophy (MD) and seven age-matched controls using the magnetic scleral search coil technique. Neuropsychological performance was assessed using the Wisconsin Card Sort Test and measures of verbal fluency. Subjects with MD showed significantly elevated error rates in the antisaccade and remembered saccade paradigms, consistent with prefrontal dysfunction, and these two measures of distractibility were significantly correlated with each other. Saccadic latencies, square wave jerk frequency, and smooth pursuit peak velocity gain showed no significant difference between the two groups, although the peak velocity of all classes of saccades was significantly reduced in patients with MD. These results extend the findings of previous studies of oculomotor function in MD, and provide novel evidence for a central contribution to abnormalities of eye movements in this condition.
采用磁性巩膜搜索线圈技术，记录了7名强直性肌营养不良（MD）患者和7名年龄匹配的对照者的反射性扫视、记忆性扫视、反扫视、注视和平稳跟踪。使用威斯康星卡片分类测验和语言流畅性测量评估神经心理学表现。MD患者在反扫视和记忆性扫视范式中的错误率显著升高，这与前额叶功能障碍一致，并且这两种注意力分散的测量方法之间显著相关。两组之间的扫视潜伏期、方波急跳频率和平稳跟踪峰值速度增益没有显著差异，尽管MD患者所有类型扫视的峰值速度均显著降低。这些结果扩展了先前关于MD患者眼动功能研究的结果，并为这种情况下眼动异常的中枢机制提供了新的证据。
