Murakami H, Adachi H, Kurihara T, Tamura Y, Kobori O, Saito K, Kurihara M
Dept. of Surgery, National Medical Center of Japan.
Gan To Kagaku Ryoho. 1995 Jul;22(8):1111-4.
We reported a patient with advanced gastric cancer and a liver metastasis, who responded remarkably to combination chemotherapy using THP, 5'-DFUR and CDDP. The patient was administered four courses of THP (15 mg/m2/day, on day 1, iv), 5'-DFUR (1400 mg/m2/day, on days 1-4 and 15-18, orally), and CDDP (80 mg/m2/day, on day 5, iv) every 4 weeks. As a result, both the primary and metastatic tumors decreased remarkably in size at more than 19 weeks (PR) and we performed curative total resection of the stomach and partial resection of the liver. Histologically, the effects of chemotherapy on gastric focus were evaluated as grade 1a and the liver metastasis completely disappeared. This combination therapy proved useful to treat advanced gastric cancer in this patient.
我们报告了1例晚期胃癌伴肝转移患者，其对采用THP、5'-DFUR和顺铂的联合化疗有显著反应。患者每4周接受4个疗程的治疗，具体方案为：THP（15mg/m²/天，第1天，静脉注射）、5'-DFUR（1400mg/m²/天，第1 - 4天和第15 - 18天，口服）和顺铂（80mg/m²/天，第5天，静脉注射）。结果，在超过19周时，原发肿瘤和转移瘤的大小均显著减小（部分缓解），我们对胃进行了根治性全切除并对肝脏进行了部分切除。组织学检查显示，化疗对胃病灶的效果评估为1a级，肝转移灶完全消失。这种联合治疗方法被证明对该患者的晚期胃癌治疗有效。
