Ishihata R, Kuwana T, Obara K, Nishimaki T, Kasukawa R
Internal Medicine, National Sanatorium Fukushima Hospital.
Gan To Kagaku Ryoho. 1995 Sep;22(10):1383-7.
A 71-year-old man with Borrmann type 3 gastric cancer with multiple liver metastases had been treated with 5'-DFUR 1400 mg/m2/day, p.o. day 1-day 4/2w and CDDP 80 mg/m2 i.v. day 5/4w, which was repeated for 4 cycles. After 2 cycle treatment, all metastatic lesions in the liver disappeared on the computed tomography scan, indicating a complete response. The primary gastric lesion was reduced, indicating a partial response. There was no significant side effect during the 4 cycles of this therapy. He is alive 6 months after the therapy with a partial response. This 5'-DFUR and CDDP combination therapy seemed to be effective for advanced gastric cancer.
一名71岁的男性，患有Borrmann 3型胃癌并伴有多处肝转移，接受了5'-脱氧氟尿苷（5'-DFUR）1400 mg/m²/天，口服，第1 - 4天/每2周，和顺铂（CDDP）80 mg/m²静脉注射，第5天/每4周的治疗，该治疗重复进行4个周期。经过2个周期的治疗后，计算机断层扫描显示肝脏内所有转移病灶均消失，提示完全缓解。原发性胃部病灶缩小，提示部分缓解。在这4个周期的治疗过程中未出现明显副作用。治疗后6个月他仍存活，处于部分缓解状态。这种5'-DFUR与CDDP联合治疗似乎对晚期胃癌有效。
