Kobayashi K, Tamaki Y, Ikenaga M, Morita T, Touno T, Mishima H, Shin E, Yagyu T, Takatsuka Y, Kikkawa N
Dept. of Surgery, Osaka National Hospital.
Gan To Kagaku Ryoho. 1994 Nov;21(15):2663-6.
We reported an experience with an advanced gastric cancer patient with direct invasion into liver and metastases to liver, who had responded extremely well to an FEP combined chemotherapy. He had curatively undergone total gastrectomy with partial hepatectomy and enlarged lymph node dissection. The patient received three courses of 5-FU (750 mg/m2/day, for four days, continuous infusion), epirubicin (30 mg/m2, on day 1, i.v.), CDDP (17.5 mg/m2/day, on days 1, 2, 3, 4 i.v.) every 3 weeks in our hospital. No remarkable side effect was encountered. Partial response in the primary and invasive lesions was observed by X-P, endoscopy and CTscan. Accordingly, we could perform curative resection of the stomach with lymph nodes and parts of liver. The effect (partial response) of neoadjuvant chemotherapy was confirmed by histological examinations. FEP combined chemotherapy appears useful as a neoadjuvant approach to advanced gastric cancer.
我们报告了一位晚期胃癌患者的治疗经历，该患者肿瘤直接侵犯肝脏并伴有肝转移，对FEP联合化疗反应极佳。他接受了根治性全胃切除术、部分肝切除术及扩大淋巴结清扫术。患者在我院每3周接受三个疗程的化疗，方案为5-氟尿嘧啶（750mg/m²/天，持续静脉滴注4天）、表柔比星（30mg/m²，第1天静脉注射）和顺铂（17.5mg/m²/天，第1 - 4天静脉注射）。未出现明显副作用。通过X线、内镜及CT扫描观察到原发灶和浸润灶出现部分缓解。因此，我们能够对胃、淋巴结及部分肝脏进行根治性切除。新辅助化疗的效果（部分缓解）通过组织学检查得以证实。FEP联合化疗作为晚期胃癌的新辅助治疗方法似乎是有效的。
