反应性关节炎和未分化血清阴性寡关节炎患者滑液中质粒和衣原体染色体DNA的扩增
Amplification of plasmid and chromosome Chlamydia DNA in synovial fluid of patients with reactive arthritis and undifferentiated seronegative oligoarthropathies.
作者信息
Bas S, Griffais R, Kvien T K, Glennås A, Melby K, Vischer T L
机构信息
Research Laboratory, University Hospital, Geneva, Switzerland.
出版信息
Arthritis Rheum. 1995 Jul;38(7):1005-13. doi: 10.1002/art.1780380718.
OBJECTIVE
To investigate the hypothesis that whole bacteria might be found in the joints of patients with Chlamydia-associated reactive arthritis.
METHODS
The presence of 2 plasmid- and 2 chromosome-specific sequences of Chlamydia DNA was investigated by amplification with the polymerase chain reaction, in synovial fluid (SF) samples from 71 patients with various arthropathies.
RESULTS
Chlamydia DNA was found in SF samples from 22 patients.
CONCLUSION
Whole chlamydiae are likely present in the SF of patients with Chlamydia-associated reactive arthritis.
目的
研究衣原体相关性反应性关节炎患者关节中可能存在完整细菌这一假说。
方法
采用聚合酶链反应扩增技术，对71例患各种关节病患者的滑液（SF）样本中衣原体DNA的2个质粒特异性序列和2个染色体特异性序列进行检测。
结果
在22例患者的滑液样本中发现衣原体DNA。
结论
衣原体相关性反应性关节炎患者的滑液中可能存在完整的衣原体。
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