Lamm M E, Nedrud J G, Kaetzel C S, Mazanec M B
Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106-4907, USA.
APMIS. 1995 Apr;103(4):241-6. doi: 10.1111/j.1699-0463.1995.tb01101.x.
The traditional role of IgA antibodies in mucosal defense has been considered as providing an immune barrier to keep exogenous substances, including microbial pathogens, from penetrating the mucosa. In this way infections can be prevented. More recently, studies in vitro and in vivo are providing evidence to suggest that IgA may have additional roles in mucosal defense. For example, during their passage through the lining epithelial cells of mucous membranes en route to the secretions, IgA antibodies may have an opportunity to neutralize intracellular pathogens like viruses. Also, IgA antibodies in the mucosal lamina propria have opportunities to complex with antigens and excrete them through the adjacent mucosal epithelium, again by the same route to the secretions that is taken by free IgA. These latter functions could aid in recovery from infection.
IgA抗体在黏膜防御中的传统作用被认为是提供一种免疫屏障，以阻止包括微生物病原体在内的外源性物质穿透黏膜。通过这种方式可以预防感染。最近，体外和体内研究提供的证据表明，IgA在黏膜防御中可能具有其他作用。例如，在其通过黏膜衬里上皮细胞到达分泌物的过程中，IgA抗体可能有机会中和病毒等细胞内病原体。此外，黏膜固有层中的IgA抗体有机会与抗原结合，并通过相邻的黏膜上皮将其排出，同样是通过游离IgA所采用的通向分泌物的相同途径。这些后期功能可能有助于从感染中恢复。
