Mazanec M B, Nedrud J G, Kaetzel C S, Lamm M E
Immunol Today. 1993 Sep;14(9):430-5. doi: 10.1016/0167-5699(93)90245-G.
Mucosal IgA has generally been viewed as an immune barrier to prevent the adherence and absorption of antigens. Recent studies employing polarized epithelial monolayers have suggested two additional functions for mucosal IgA. One is to neutralize intracellular microbial pathogens, such as viruses, directly within epithelial cells. The second is to bind antigens in the mucosal lamina propria and excrete them through the adjacent epithelium into the lumen, thereby ridding the body of locally formed immune complexes and decreasing their access to the systemic circulation.
黏膜IgA通常被视为一种免疫屏障，可防止抗原的黏附和吸收。最近利用极化上皮单层细胞进行的研究表明，黏膜IgA还有另外两种功能。一是直接在上皮细胞内中和细胞内微生物病原体，如病毒。二是在黏膜固有层结合抗原，并通过相邻上皮细胞将其排泄到管腔中，从而清除体内局部形成的免疫复合物，并减少它们进入体循环的机会。
