Gough N M, Rakar S, Hovens C M, Wilks A
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Mamm Genome. 1995 Apr;6(4):255-6. doi: 10.1007/BF00352411.
We have mapped the gene encoding the murine RYK growth factor receptor protein tyrosine kinase by genetic linkage analysis with recombinant inbred strains of mouse. Two distinct Ryk loci (Ryk-1 and Ryk-2) were identified. Ryk-1 mapped to Chromosome (Chr) 9, whereas Ryk-2 mapped to Chr 12. A similar arrangement of RYK-related loci was previously determined in the human. Synteny has already been established between murine Chr 9 in the region of Ryk-1, and human chromosome 3q11-12, the location of the human RYK-1 gene. However, the Ryk-2/RYK-2 loci on murine Chr 12 and human Chr 17p13.3 define a new region of synteny.
我们通过与小鼠重组近交系进行遗传连锁分析，绘制了编码鼠源RYK生长因子受体蛋白酪氨酸激酶的基因图谱。鉴定出了两个不同的Ryk基因座（Ryk-1和Ryk-2）。Ryk-1定位于9号染色体（Chr），而Ryk-2定位于12号染色体。之前在人类中也确定了类似的RYK相关基因座排列。已经在Ryk-1区域的鼠源9号染色体与人类3q11-12染色体（人类RYK-1基因的位置）之间建立了同线性关系。然而，鼠源12号染色体上的Ryk-2/RYK-2基因座与人类17p13.3染色体定义了一个新的同线性区域。
