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基于重组近交系分析的基因连锁估计的置信限

Confidence limits for estimates of gene linkage based on analysis of recombinant inbred strains.

作者信息

Silver J

出版信息

J Hered. 1985 Nov-Dec;76(6):436-40. doi: 10.1093/oxfordjournals.jhered.a110140.

DOI:10.1093/oxfordjournals.jhered.a110140
PMID:4086787
Abstract

Recombinant inbred (RI) strains are extremely useful for genetic mapping. This paper presents a simple method for determining confidence intervals for linkage estimates based on analysis of RI strains. The results show that such confidence intervals are usually large with the currently available numbers of RI strains. Therefore, map positions based only on analysis of RI strains should be interpreted with caution. To facilitate interpretation of linkage data derived from RI strains, a table is presented giving the 95 percent and 99 percent confidence intervals for all possible linkages detected with up to 45 RI strains.

摘要

重组近交（RI）品系对于基因定位极为有用。本文提出了一种基于RI品系分析来确定连锁估计置信区间的简单方法。结果表明，就目前可用的RI品系数量而言，此类置信区间通常较大。因此，仅基于RI品系分析得出的图谱位置应谨慎解读。为便于解读源自RI品系的连锁数据，文中给出了一个表格，列出了在多达45个RI品系中检测到的所有可能连锁的95%和99%置信区间。

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