白细胞介素4及其他5q31.1染色体标记与血清总免疫球蛋白E浓度的连锁分析。
Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations.
作者信息
Marsh D G, Neely J D, Breazeale D R, Ghosh B, Freidhoff L R, Ehrlich-Kautzky E, Schou C, Krishnaswamy G, Beaty T H
机构信息
Johns Hopkins Asthma and Allergy Center, School of Medicine, Baltimore, MD 21224.
出版信息
Science. 1994 May 20;264(5162):1152-6. doi: 10.1126/science.8178175.
Sib-pair analysis of 170 individuals from 11 Amish families revealed evidence for linkage of five markers in chromosome 5q31.1 with a gene controlling total serum immunoglobulin E (IgE) concentration. No linkage was found between these markers and specific IgE antibody concentrations. Analysis of total IgE within a subset of 128 IgE antibody-negative sib pairs confirmed evidence for linkage to 5q31.1, especially to the interleukin-4 gene (IL4). A combination of segregation and maximum likelihood analyses provided further evidence for this linkage. These analyses suggest that IL4 or a nearby gene in 5q31.1 regulates IgE production in a nonantigen-specific (noncognate) fashion.
对来自11个阿米什家族的170名个体进行的同胞对分析显示，5号染色体5q31.1区域的五个标记与一个控制总血清免疫球蛋白E（IgE）浓度的基因存在连锁证据。这些标记与特异性IgE抗体浓度之间未发现连锁关系。对128对IgE抗体阴性同胞对的一个子集内的总IgE进行分析，证实了与5q31.1存在连锁的证据，特别是与白细胞介素-4基因（IL4）。分离分析和最大似然分析相结合为这种连锁提供了进一步证据。这些分析表明，IL4或5q31.1区域附近的一个基因以非抗原特异性（非同源）方式调节IgE的产生。
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