Dunér K I
Chromogenix AB, Mölndal, Sweden.
PDA J Pharm Sci Technol. 1995 May-Jun;49(3):119-21.
Commercial pharmaceutical waters were evaluated regarding their interference in the chromogenic Limulus Amebocyte Lysate (LAL) test. Two of the four tested waters strongly inhibited the U.S. Reference Standard Endotoxin, while a Control Standard Endotoxin was less affected. The inhibitory effect could be mimiced by adding trace amounts of certain metal ions to a non-interfering water. In conclusion, the water used in the LAL test must be chosen with great care.
对市售药用纯化水在显色鲎试剂法（LAL）检测中的干扰情况进行了评估。在四种受试纯化水中，有两种对美国内毒素参考标准品有强烈抑制作用，而对照标准内毒素受影响较小。向无干扰的纯化水中添加痕量的某些金属离子可模拟出这种抑制作用。总之，鲎试剂法检测中所用的纯化水必须谨慎选择。
