Harada E, Hashimoto Y, Syuto B
Department of Veterinary Physiology, Faculty of Agriculture, Tottori University, Japan.
Comp Biochem Physiol A Physiol. 1995 Jul;111(3):479-85. doi: 10.1016/0300-9629(95)00023-z.
The effect of repeated oral administration of polydextrose and pectin on intestinal macromolecular transport and digestive enzymes development was examined in the suckling rat. The administration of polydextrose for 7 days resulted in pancreatic hyperplasia, followed by the enhancement of trypsin activity. The length of the small intestine and the wet weight of the cecum were significantly increased by polydextrose treatment. Maltase activity was increased in a dose dependent manner by polydextrose, but not by pectin treatment. Lactase activity was not changed by either treatment. The absorption of bovine IgG was precociously depressed by polydextrose, but not by pectin treatment. These results suggest that oral administration of polydextrose induces precocious maturation of the small intestine and exocrine pancreas in the suckling rat.
在乳鼠中研究了重复口服聚葡萄糖和果胶对肠道大分子转运及消化酶发育的影响。连续7天给予聚葡萄糖导致胰腺增生，随后胰蛋白酶活性增强。聚葡萄糖处理显著增加了小肠长度和盲肠湿重。聚葡萄糖以剂量依赖方式增加麦芽糖酶活性，但果胶处理未使其增加。两种处理均未改变乳糖酶活性。聚葡萄糖可过早抑制牛IgG的吸收，但果胶处理无此作用。这些结果表明，口服聚葡萄糖可诱导乳鼠小肠和外分泌胰腺过早成熟。
