Harada E, Syuto B
Department of Physiology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Biol Neonate. 1993;63(1):52-60. doi: 10.1159/000243908.
The effect of endogenous and exogenous secretin on the intestinal closure of macromolecular transmission and maltase development were investigated in suckling rats. The increase in secretin-like immunoreactivity with orogastric infusion of HCl solution in 14 day-old pups was confirmed. By the repeated oral administration of HCl, pancreatic hyperplasia, suppression of intestinal bovine IgG transmission, and precocious induction of maltase activity were occurred. By repeated subcutaneous injection of secretin, dose-dependent suppression of intestinal bovine IgG absorption and increase in maltase activity were observed. The suppression of IgG absorption with secretin treatment was also observed in adrenalectomized pups. These results suggest that secretin affects the maturation of gastrointestinal function in suckling rats.
研究了内源性和外源性促胰液素对乳鼠肠道大分子物质转运封闭及麦芽糖酶发育的影响。证实了在14日龄幼鼠经口胃灌注盐酸溶液后促胰液素样免疫反应性增加。通过反复口服盐酸，出现了胰腺增生、肠道牛IgG转运受抑制以及麦芽糖酶活性的早熟诱导。通过反复皮下注射促胰液素，观察到肠道牛IgG吸收呈剂量依赖性抑制以及麦芽糖酶活性增加。在肾上腺切除的幼鼠中也观察到促胰液素治疗对IgG吸收的抑制作用。这些结果表明促胰液素影响乳鼠胃肠功能的成熟。
