Guis F, Ville Y, Vincent Y, Doumerc S, Pons J C, Frydman R
Unité de Médecine foetale et de Diagnostic Antenatal, Hôpital Antoine Béclère, Clamart, France.
Ultrasound Obstet Gynecol. 1995 May;5(5):304-7. doi: 10.1046/j.1469-0705.1995.05050304.x.
Subtle facial abnormalities, including smallness of the nose, are common findings in trisomy 21 and numerous other genetic conditions. The aim of this study was to construct a normal range for the length of the fetal nasal bones with gestation in a Caucasian population. Ultrasound measurements were performed on a strictly mid-sagittal profile in 376 normal singleton fetuses at 14-34 (mean 24) weeks' gestation. It was found that the length of the nasal bones increased from 4 mm at 14 weeks to 12 mm at 35 weeks' gestation, and that there was a linear relationship between the length of these bones and biparietal diameter and femur length. We conclude that the length of nasal bones can easily be measured in fetuses at 14-34 weeks' gestation and that such measurements might prove useful in the evaluation of pregnancies at high risk for associated fetal abnormalities.
细微的面部异常，包括鼻子短小，是21三体综合征及许多其他遗传疾病的常见表现。本研究的目的是建立白种人群中胎儿鼻骨长度随孕周变化的正常范围。对376例孕14 - 34周（平均24周）的正常单胎胎儿进行严格的正中矢状切面超声测量。结果发现，鼻骨长度从孕14周时的4毫米增加到孕35周时的12毫米，且这些骨骼的长度与双顶径和股骨长度之间存在线性关系。我们得出结论，孕14 - 34周胎儿的鼻骨长度易于测量，且这种测量可能对评估有相关胎儿异常高风险的妊娠有用。
