Lourenço Cátia, Brito Conceição, Ruano Luís, Vilhena Ana, Sousa Mariana, Afreixo Vera, Costa Horácio
Obstetrics, Entre Douro e Vouga Local Health Unit, Santa Maria da Feira, PRT.
Department of Obstetrics and Gynecology, Gaia/Espinho Local Health Unit, Vila Nova de Gaia, PRT.
Cureus. 2025 Aug 15;17(8):e90129. doi: 10.7759/cureus.90129. eCollection 2025 Aug.
To determine sonographic dimensions of the fetal upper, middle and lower facial profile levels in normal pregnancy at the second trimester scan (20-22 weeks).
This was a prospective, cross-sectional study of 400 normal healthy fetuses at 20-22 weeks of gestation. The sagittal plane of the fetal facial profile was evaluated using transabdominal ultrasound. The three levels of the face were defined as it follows: a vertical line was drawn from the anterior edge of the sphenoid bone and then four parallel lines were drawn parallel to the long axis of the maxilla passing through the inflection point of the frontal bone, the nasion, the superior border of the maxilla and the gnathion.
The study population consisted of 400 low-risk pregnancies at 20-22 weeks gestation. We provided normative data in centiles of height and depth of upper, middle and lower levels of the fetal profile.
We provide normative data of the three levels (upper, middle and lower) of the fetal facial profile between 20-22 weeks. Our data offer a potential tool for the prenatal diagnosis of craniofacial anomalies and a comparative study with trisomy 21 fetuses currently underway.
确定孕中期扫描（20 - 22周）正常妊娠胎儿面部上、中、下轮廓水平的超声测量尺寸。
这是一项对400例妊娠20 - 22周的正常健康胎儿进行的前瞻性横断面研究。使用经腹超声评估胎儿面部轮廓的矢状面。面部的三个水平定义如下：从蝶骨前缘画一条垂直线，然后画四条与上颌骨长轴平行的平行线，分别经过额骨的拐点、鼻根、上颌骨上缘和下颌骨最低点。
研究对象为400例妊娠20 - 22周的低风险孕妇。我们提供了胎儿轮廓上、中、下水平高度和深度的百分位数规范数据。
我们提供了20 - 22周胎儿面部轮廓三个水平（上、中、下）的规范数据。我们的数据为产前诊断颅面畸形提供了一个潜在工具，并且目前正在进行与21三体胎儿的比较研究。
