Bonine F L
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Feb;79(2):154-7; discussion 157-8. doi: 10.1016/s1079-2104(05)80273-2.
This nonrandomized prospective study was conducted in a private practice setting to determine the effect of a 0.12% chlorhexidine gluconate rinse (Peridex, Proctor and Gamble, Cincinnati, Ohio) on the incidence of dry socket after removal of impacted mandibular third molars. Over a 3-year period, 371 patients (total of 654 impacted mandibular third molars) received either no treatment (group 1), 2 weeks of twice daily Peridex rinse postsurgery (group 2), or one rinse presurgery (group 3). The group that used Peridex twice daily for 2 weeks after surgery (group 2) showed a significant reduction (56%) in the incidence of dry socket when compared with either the group that did not rinse (group 1) or the group that rinsed only once just before surgery (group 3). The incidence of dry socket was higher in smokers and in females who used oral contraceptives. Twice daily use of Peridex for 2 weeks also yielded significant reductions in dry socket in smokers, nonsmokers, and in females who did not use oral contraceptives. Results from this study demonstrate that the use of Peridex for 2 weeks after surgery is effective in prevention of dry socket after surgical extraction of impacted molars.
这项非随机前瞻性研究在私人诊所环境中进行，以确定0.12%葡萄糖酸氯己定漱口水（Peridex，宝洁公司，俄亥俄州辛辛那提）对拔除下颌阻生第三磨牙后干槽症发生率的影响。在3年期间，371例患者（共654颗下颌阻生第三磨牙）分别接受了无治疗（第1组）、术后每天两次使用Peridex漱口水2周（第2组）或术前一次漱口水（第3组）。术后每天两次使用Peridex漱口水2周的组（第2组）与未进行漱口水治疗的组（第1组）或仅在术前进行一次漱口水治疗的组（第3组）相比，干槽症发生率显著降低（56%）。吸烟者和使用口服避孕药的女性干槽症发生率较高。术后每天两次使用Peridex漱口水2周在吸烟者、非吸烟者以及未使用口服避孕药的女性中也显著降低了干槽症发生率。这项研究的结果表明，术后使用Peridex漱口水2周对预防拔除阻生磨牙后的干槽症有效。
