Larsen P E
Department of Oral and Maxillofacial Surgery, College of Dentistry, Ohio State University, Columbus 43210.
J Oral Maxillofac Surg. 1991 Sep;49(9):932-7. doi: 10.1016/0278-2391(91)90055-q.
A prospective randomized double-blind placebo-controlled study was conducted with 139 patients (278 bilaterally impacted mandibular third molars) to determine the effect of a perioperative 0.12% chlorhexidine gluconate rinse on the incidence of alveolar osteitis following surgical removal of impacted mandibular third molars. A statistically significant 60% reduction in the incidence of alveolar osteitis was obtained in the chlorhexidine group compared with the placebo group. In most subgroups analyzed, chlorhexidine was associated with at least a 50% reduction in alveolar osteitis compared with control groups.
对139例患者（278颗双侧阻生下颌第三磨牙）进行了一项前瞻性随机双盲安慰剂对照研究，以确定围手术期使用0.12%葡萄糖酸氯己定冲洗对阻生下颌第三磨牙手术拔除后牙槽骨炎发生率的影响。与安慰剂组相比，氯己定组牙槽骨炎的发生率显著降低了60%。在大多数分析的亚组中，与对照组相比，氯己定使牙槽骨炎的发生率至少降低了50%。
