Odell E W, Hodgson R P, Haskell R
Department of Oral Medicine and Pathology, UMDS, Guy's Hospital, London, United Kingdom.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Apr;79(4):459-61. doi: 10.1016/s1079-2104(05)80128-3.
Minocycline hydrochloride is a semisynthetic tetracycline derivative used widely for the treatment of acne vulgaris. Among its side effects is the ability to pigment many tissues particularly thyroid, skin, tooth, and bone. A case is presented in which long-term minocycline therapy (500 g taken orally over 11 years) resulted in dark bone pigmentation (black bone disease) severe enough to be visible through the alveolar and palatal mucosa. No skin or tooth pigmentation was present.
盐酸米诺环素是一种半合成四环素衍生物，广泛用于治疗寻常痤疮。其副作用之一是能够使许多组织色素沉着，尤其是甲状腺、皮肤、牙齿和骨骼。本文报告一例长期服用米诺环素治疗（11年间口服500克）导致骨骼色素沉着（黑骨病）严重到通过牙槽和腭黏膜即可看见的病例。未出现皮肤或牙齿色素沉着。
