Caprioli A, Markowska A L, Olton D S
Institute for Research on Senescence, Sigma Tau, Rome, Italy.
J Gerontol A Biol Sci Med Sci. 1995 Jul;50(4):B232-36. doi: 10.1093/gerona/50a.4.b232.
Chronic Acetyl-L-Carnitine (ALCAR) treatment prevents some age-related memory impairment. The present experiment examined the effects of aging and ALCAR in Fischer 344 rats on retention of spatial discrimination test in a familiar environment (FE), and on the acquisition of a spatial discrimination in a novel environment (NE). Rats 18 months or 3 months old were trained with a new procedure to assess spatial discrimination in the Morris water maze. Performance during acquisition in FE was used to assign each old rat to one of two classes: Good Performers (GP) and Poor Performers (PP) based on their swim time to reach the platform. The old rats displayed heterogeneous performance and a spatial discrimination deficit. Chronic ALCAR treatment enhanced spatial acquisition in the NE of rats with age-related behavioral impairments and had a slight effect on retention of the spatial discrimination in the FE.
长期乙酰左旋肉碱（ALCAR）治疗可预防一些与年龄相关的记忆障碍。本实验研究了衰老和ALCAR对Fischer 344大鼠在熟悉环境（FE）中空间辨别测试的记忆保持以及在新环境（NE）中空间辨别的习得的影响。对18个月或3个月大的大鼠采用一种新程序进行训练，以评估其在莫里斯水迷宫中的空间辨别能力。根据在FE中习得过程中的表现，将每只老年大鼠分为两类：表现良好者（GP）和表现较差者（PP），分类依据是它们游到平台的时间。老年大鼠表现出异质性表现和空间辨别缺陷。长期ALCAR治疗可增强有年龄相关行为障碍的大鼠在NE中的空间习得能力，对FE中空间辨别的记忆保持有轻微影响。
