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对成年双胞胎的身高、体重和体重指数进行的横断面检查。

A cross-sectional examination of height, weight, and body mass index in adult twins.

作者信息

Carmichael C M, McGue M

机构信息

Department of Psychology, University of Minnesota, USA.

出版信息

J Gerontol A Biol Sci Med Sci. 1995 Jul;50(4):B237-44. doi: 10.1093/gerona/50a.4.b237.

Abstract

A cross-sectional twin design was used to study the developmental nature of genetic and environmental influences on height, weight, and body mass index. The sample of same-sex adult male and female twins consisted of 586 monozygotic and 447 like-sex dizygotic twin pairs aged 18 to 81 years. Means and variances suggested normative age differences for all three physical variables. Biometrical model-fitting with maximum likelihood methods of parameter estimation indicated that the general best-fitting model across the age groups for height, weight, and body mass index was one in which the genetic effects were additive and the environmental effects were from nonshared, idiosyncratic experiences. The best-fitting cross-sectional biometrical model for height, weight, and body mass index indicated that additive genetic variance remained stable while nonshared environmental variance increased with age. This increase in environmental variance but stable genetic variance resulted in decreasing heritability with age for height (heritability ranging from 0.89 in the youngest group to 0.87 in the oldest), weight (heritability ranging from 0.86 in the youngest group to 0.70 in the oldest), and body mass index (heritability ranging from 0.82 in the youngest group to 0.63 in the oldest).

摘要

采用横断面双胞胎设计来研究遗传和环境因素对身高、体重及体重指数发育的影响。同性别成年男性和女性双胞胎样本包括586对单卵双胞胎和447对同性异卵双胞胎,年龄在18至81岁之间。均值和方差表明所有这三个身体变量存在正常的年龄差异。采用最大似然参数估计方法进行生物统计学模型拟合表明,身高、体重和体重指数在各年龄组中总体最佳拟合模型是遗传效应为加性效应且环境效应来自非共享的、独特经历的模型。身高、体重和体重指数的最佳拟合横断面生物统计学模型表明,加性遗传方差保持稳定,而非共享环境方差随年龄增加。环境方差的这种增加但遗传方差稳定导致身高(遗传率从最年轻组的0.89降至最年长组的0.87)、体重(遗传率从最年轻组的0.86降至最年长组的0.70)和体重指数(遗传率从最年轻组的0.82降至最年长组的0.63)的遗传率随年龄下降。

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