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平菇子实体含有3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂——洛伐他汀。

Pleurotus fruiting bodies contain the inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase-lovastatin.

作者信息

Gunde-Cimerman N, Cimerman A

机构信息

National Institute of Chemistry, Laboratory for Biotechnology and Industrial Mycology, Ljubljana, Slovenia.

出版信息

Exp Mycol. 1995 Mar;19(1):1-6. doi: 10.1006/emyc.1995.1001.

DOI:10.1006/emyc.1995.1001
PMID:7614366
Abstract

In the fruiting bodies of the fungus Pleurotus ostreatus, also called the oyster mushroom, we found a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase-lovastatin. The appearance of the inhibitor during the development of fruiting bodies was followed and lovastatin determined in the vegetative mycelium, in the primordia, as well as in different parts of sporocarps of different sizes. Less lovastatin was found in stripes as compared to pili or in mature stages in the lamellae and basidiospores.

摘要

在真菌平菇(又称蚝菇)的子实体中,我们发现了一种3-羟基-3-甲基戊二酰辅酶A还原酶的竞争性抑制剂——洛伐他汀。我们追踪了抑制剂在子实体发育过程中的出现情况,并测定了其在营养菌丝体、原基以及不同大小子实体不同部位中的含量。与菌柄相比,菌褶中洛伐他汀的含量较少,在菌褶和担孢子的成熟阶段也是如此。

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Exp Mycol. 1995 Mar;19(1):1-6. doi: 10.1006/emyc.1995.1001.
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