Petroff O A, Rothman D L, Behar K L, Mattson R H
Department of Neurology, Yale University, New Haven, CT 06510, USA.
Epilepsia. 1995 May;36(5):457-64. doi: 10.1111/j.1528-1157.1995.tb00486.x.
Recent developments involving 1H nuclear magnetic resonance (NMR) spectroscopic editing techniques have allowed noninvasive measurements of gamma-aminobutyric acid (GABA) in human cerebrum. The additional information gained from GABA and macromolecule measurements permitted more precise glutamate (Glu) and glutamine (Gln) measurements. Occipital lobe GABA in 10 nonepileptic, healthy subjects was 1.0 mumol/g brain [95% confidence interval (CI) 0.9-1.1]. Vigabatrin (VGB) is a safe and effective antiepileptic drug (AED) that irreversibly inhibits neuronal and glial GABA-transaminase. GABA levels were increased in all patients treated with VGB. With a standard dose of 3-6 g/day, GABA levels were 2.6 mumol/g (95% CI 2.3-2.8). Mean occipital GABA level measured in epileptic patients not receiving VGB was 0.9 mumol/g (95% CI 0.7-1.1). Gln was increased by 1.9 mumol/g and Glu was decreased by 0.8 mumol/g in patients receiving VGB as compared with patients receiving standard medications alone.
近期涉及氢核磁共振（NMR）光谱编辑技术的进展使得能够对人类大脑中的γ-氨基丁酸（GABA）进行无创测量。从GABA和大分子测量中获得的额外信息使得谷氨酸（Glu）和谷氨酰胺（Gln）的测量更加精确。10名非癫痫健康受试者枕叶的GABA含量为1.0微摩尔/克脑[95%置信区间（CI）0.9 - 1.1]。氨己烯酸（VGB）是一种安全有效的抗癫痫药物（AED），可不可逆地抑制神经元和胶质细胞的GABA转氨酶。所有接受VGB治疗的患者GABA水平均升高。标准剂量为每日3 - 6克时，GABA水平为2.6微摩尔/克（95% CI 2.3 - 2.8）。未接受VGB治疗的癫痫患者枕叶GABA平均水平为0.9微摩尔/克（95% CI 0.7 - 1.1）。与仅接受标准药物治疗的患者相比，接受VGB治疗的患者Gln增加了1.9微摩尔/克，Glu减少了0.8微摩尔/克。
