Iijima R, Kisugi J, Yamazaki M
Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan.
Dev Comp Immunol. 1995 Jan-Feb;19(1):13-9. doi: 10.1016/0145-305x(94)00055-k.
We observed for the first time that antifungal activity was exhibited by Aplysianin E (AKE), an antineoplastic and antibacterial glycoprotein purified from the eggs of Aplysia kurodai. AKE completely suppressed growth of the yeast form fungi, Saccharomyces cerevisiae A 5 8 1 A, Schizosaccharomyces pombe JY 1 and Candida albicans ATCC 36232 at a concentration of over 16 micrograms/mL. The colony-forming abilities of the fungi were also significantly decreased after contact with AKE. These results indicate that AKE has an antifungal property and that its mode of action is fungicidal.
我们首次观察到，从黑指纹海兔卵中纯化得到的一种具有抗肿瘤和抗菌活性的糖蛋白——海兔素E（AKE）表现出抗真菌活性。在浓度超过16微克/毫升时，AKE能完全抑制酵母型真菌酿酒酵母A581A、粟酒裂殖酵母JY1和白色念珠菌ATCC 36232的生长。与AKE接触后，这些真菌的集落形成能力也显著下降。这些结果表明，AKE具有抗真菌特性，其作用方式为杀菌。
