Iijima R, Kisugi J, Yamazaki M
Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan.
Biol Pharm Bull. 1994 Aug;17(8):1144-6. doi: 10.1248/bpb.17.1144.
Dolabellanin A (DAA), the antineoplastic and antibacterial glycoprotein purified from the albumen gland of Dolabella auricularia, showed an antifungal activity. DAA suppressed fungal growth completely at a concentration of over 2 micrograms/ml, and the colony forming ability of the fungus was significantly decreased after contact with DAA. These results indicate that DAA is an antifungal protein and its mode of antifungal activity is fungicidal.
多拉贝宁A（DAA）是从耳状海兔蛋白腺中纯化得到的具有抗肿瘤和抗菌活性的糖蛋白，它具有抗真菌活性。DAA在浓度超过2微克/毫升时能完全抑制真菌生长，且真菌与DAA接触后其菌落形成能力显著下降。这些结果表明DAA是一种抗真菌蛋白，其抗真菌活性模式为杀菌作用。
