膳食饱和脂肪酸：一种治疗酒精性肝病的新方法。

Dietary saturated fatty acids: a novel treatment for alcoholic liver disease.

作者信息

Nanji A A, Sadrzadeh S M, Yang E K, Fogt F, Meydani M, Dannenberg A J

机构信息

Department of Pathology, New England Deaconess Hospital, Boston, Massachusetts, USA.

出版信息

Gastroenterology. 1995 Aug;109(2):547-54. doi: 10.1016/0016-5085(95)90344-5.

DOI:10.1016/0016-5085(95)90344-5

PMID:7615205

Abstract

BACKGROUND & AIMS: Lipid peroxidation may be important in the pathogenesis of alcoholic liver injury. The purpose of this study was to determine whether a saturated fatty acid-based therapy (palm oil) could decrease lipid peroxidation and alcoholic liver injury during ethanol withdrawal.

METHODS

Three groups of male Wistar rats (5 rats/group) were studied. Rats in group 1 were fed a fish oil-ethanol diet for 6 weeks; rats in groups 2 and 3 were fed a fish oil-ethanol diet for 6 weeks before treatment with fish oil-dextrose (group 2) or palm oil-dextrose (group 3) for 2 weeks. Liver samples were analyzed for histopathology, lipid peroxidation, fatty acid composition, cytochrome P450 2E1 activity, and tocopherol levels.

RESULTS

By 6 weeks, all rats had developed fatty liver, inflammation, and necrosis. Group 2 showed minimal histological improvement, whereas group 3 showed near normalization of the histology. The improvement in group 3 was associated with decreased lipid peroxidation and P450 2E1 activity. Higher levels of omega-3 fatty acids were detected in group 2 than group 3. Tocopherol levels were similar among the groups.

CONCLUSIONS

A diet enriched in saturated but not unsaturated fatty acids reversed alcoholic liver injury. This effect may be explained by down-regulation of lipid peroxidation.

摘要

背景与目的

脂质过氧化在酒精性肝损伤的发病机制中可能起重要作用。本研究的目的是确定基于饱和脂肪酸的疗法（棕榈油）是否能在乙醇戒断期间减少脂质过氧化和酒精性肝损伤。

方法

对三组雄性Wistar大鼠（每组5只）进行研究。第1组大鼠喂食鱼油 - 乙醇饮食6周；第2组和第3组大鼠在喂食鱼油 - 乙醇饮食6周后，分别用鱼油 - 葡萄糖（第2组）或棕榈油 - 葡萄糖（第3组）治疗2周。对肝脏样本进行组织病理学、脂质过氧化、脂肪酸组成、细胞色素P450 2E1活性和生育酚水平分析。