Watson R G, Angus P W, Dewar M, Goss B, Sewell R B, Smallwood R A
Gastroenterology Unit, Heidelberg Repatriation Hospital, Melbourne, Australia.
Gut. 1995 Jun;36(6):927-30. doi: 10.1136/gut.36.6.927.
A prevalence study of primary biliary cirrhosis was carried out in the state of Victoria, Australia, by means of a mail survey of specialist physicians and a review of hospital records. Eighty four cases were identified, giving a prevalence of 19.1 per million population (95% confidence limits (CI) 15.3, 23.7), which is among the lowest in published reports. The prevalence in the Australian born, at risk population (women over the age of 24) was 51 per million (95% CI 37.5, 67.9). Both these figures are considerably lower than those in populations of similar age distribution in the UK and northern Europe. Since most Victorians are descended from British or European settlers, the low prevalence of primary biliary cirrhosis in this study supports the hypothesis that local environmental factors may be important in the pathogenesis of this disease.
澳大利亚维多利亚州通过对专科医生进行邮件调查并查阅医院记录，开展了一项原发性胆汁性肝硬化患病率研究。共识别出84例病例，患病率为每百万人口19.1例（95%置信区间（CI）为15.3至23.7），这是已发表报告中最低的患病率之一。在澳大利亚出生的高危人群（24岁以上女性）中，患病率为每百万人口51例（95% CI为37.5至67.9）。这两个数字均显著低于英国和北欧年龄分布相似人群中的患病率。由于大多数维多利亚人是英国或欧洲定居者的后裔，本研究中原发性胆汁性肝硬化的低患病率支持了以下假设：当地环境因素可能在该疾病的发病机制中起重要作用。
