Witt-Sullivan H, Heathcote J, Cauch K, Blendis L, Ghent C, Katz A, Milner R, Pappas S C, Rankin J, Wanless I R
Department of Medicine, University of Toronto, Ontario, Canada.
Hepatology. 1990 Jul;12(1):98-105. doi: 10.1002/hep.1840120116.
The demographics of primary biliary cirrhosis in Ontario, Canada, are described. Two hundred and twenty-five primary biliary cirrhosis patients were identified by 85 of 502 gastroenterologists (or internists) practicing in Ontario acute care hospitals that have 150 or more beds. Two hundred and six patients were verified as being antimitochondrial antibody-positive, resulting in an incidence of 3.26 per million per year and a prevalence of 22.39 per million. Questionnaire data were obtained on 88.5% of these patients. Twenty-nine percent of the patients were found to be asymptomatic. Geographical clustering and racial predisposition were not seen. No increase in breast cancer prevalence was noted. By the time the diagnosis of primary biliary cirrhosis was established, the patients had consulted a median number of 3.5 physicians. Fatigue was reported as the most disabling symptom. The diagnosis of primary biliary cirrhosis in patients referred from across the province of Ontario was independently confirmed by us, using standard criteria (antimitochondrial antibody testing and liver biopsy), and was found to be reliable.
本文描述了加拿大安大略省原发性胆汁性肝硬化的人口统计学特征。在安大略省拥有150张或更多床位的急症护理医院执业的502名胃肠病学家（或内科医生）中的85人，共识别出225例原发性胆汁性肝硬化患者。其中206例患者被证实抗线粒体抗体呈阳性，年发病率为每百万人口3.26例，患病率为每百万人口22.39例。对其中88.5%的患者获取了问卷调查数据。发现29%的患者无症状。未观察到地理聚集性和种族易感性。未发现乳腺癌患病率增加。在原发性胆汁性肝硬化确诊时，患者平均已咨询过3.5名医生。疲劳被报告为最具致残性的症状。我们使用标准标准（抗线粒体抗体检测和肝活检），对从安大略省全省转诊来的患者的原发性胆汁性肝硬化诊断进行了独立确认，发现该诊断是可靠的。
