Starck W J, Epker B N
Department of Oral and Maxillofacial Surgery, John Peter Smith Hospital, Fort Worth, Texas 76104, USA.
Int J Oral Maxillofac Implants. 1995 Jan-Feb;10(1):74-8.
Late loss of initially integrated endosseous implants has generally been attributed to implant overload often the result of inappropriate prosthesis design. Implant placement is rarely contraindicated by preexisting systemic diseases, and no instances of medication-induced implant failure have been reported in the literature. This paper reports a case in which a patient lost five endosseous implants that had successfully osseointegrated and had been restored with a lower hybrid prosthesis approximately 6 months after diphosphonate therapy for osteoporosis was started.
最初成功植入的骨内种植体的后期丢失通常归因于种植体过载，这往往是假体设计不当所致。全身疾病很少会成为种植体植入的禁忌证，且文献中未报道过药物导致种植体失败的病例。本文报告了一例患者，该患者在开始使用双膦酸盐治疗骨质疏松症约6个月后，丢失了5颗已成功实现骨结合并采用下颌混合假体修复的骨内种植体。
