Del Bigio M R
Department of Pathology, Health Sciences Centre, Winnipeg, Canada.
Glia. 1995 May;14(1):1-13. doi: 10.1002/glia.440140102.
This review summarizes the current scientific literature concerning the ependymal lining of the cerebral ventricles of the brain with an emphasis on selective barrier function and protective roles for the common ependymal cell. Topics covered include the development, morphology, protein and enzyme expression including reactive changes, and pathology. Some cells lining the neural tube are committed at an early stage to becoming ependymal cells. They serve a secretory function and perhaps act as a cellular/axonal guidance system, particularly during fetal development. In the mature mammalian brain ependymal cells possess the structural and enzymatic characteristics necessary for scavenging and detoxifying a wide variety of substances in the CSF, thus forming a metabolic barrier at the brain-CSF interface.
本综述总结了当前有关脑室室管膜衬里的科学文献，重点关注普通室管膜细胞的选择性屏障功能和保护作用。涵盖的主题包括发育、形态学、蛋白质和酶表达（包括反应性变化）以及病理学。神经管内衬的一些细胞在早期就确定会成为室管膜细胞。它们具有分泌功能，可能还充当细胞/轴突导向系统，尤其是在胎儿发育期间。在成熟的哺乳动物大脑中，室管膜细胞具有清除和解毒脑脊液中多种物质所需的结构和酶学特征，从而在脑-脑脊液界面形成代谢屏障。
