Palmø J, Asp S, Daugaard J R, Richter E A, Klokker M, Pedersen B K
Copenhagen Muscle Research Centre, Department of Infectious Diseases, Rigshospitalet, Denmark.
J Appl Physiol (1985). 1995 Apr;78(4):1442-6. doi: 10.1152/jappl.1995.78.4.1442.
The effect of eccentric one-legged exercise on natural killer (NK) cell activity was studied in eight healthy males. To distinguish between local and systemic effects, blood samples were collected from veins in the exercising leg and resting arm. However, the results did not significantly differ between the leg and arm. To eliminate diurnal variations, the results were compared with a control group that did not exercise but had blood samples collected at the same time points. In the exercising group, plasma creatine kinase increased progressively during and up to 4 days after exercise. The percentage of CD16+ NK cells increased during exercise, which was paralleled by an increase in the NK cell activity per fixed number of blood mononuclear cells. The NK cell activity on a per NK cell basis did not change. The percentage of CD3+, CD4+, CD8+, CD19+, and CD14+ cells did not change significantly during exercise. The present study thus showed that eccentric exercise with a relatively small muscle mass (1 quadriceps femoris muscle) causes systemic effects on NK cells. It is suggested that the increase in plasma epinephrine during eccentric exercise is responsible for the observed increase in the percentage of CD16+ cells.
在八名健康男性中研究了离心单腿运动对自然杀伤（NK）细胞活性的影响。为了区分局部和全身效应，从运动腿和静止手臂的静脉采集血样。然而，腿部和手臂的结果没有显著差异。为了消除昼夜变化，将结果与未运动但在相同时间点采集血样的对照组进行比较。在运动组中，血浆肌酸激酶在运动期间及运动后4天内逐渐升高。运动期间CD16 + NK细胞的百分比增加，同时每固定数量的血液单核细胞中的NK细胞活性也增加。基于每个NK细胞的NK细胞活性没有变化。运动期间CD3 +、CD4 +、CD8 +、CD19 +和CD14 +细胞的百分比没有显著变化。因此，本研究表明，肌肉质量相对较小（一块股四头肌）的离心运动对NK细胞产生全身效应。有人认为，离心运动期间血浆肾上腺素的增加是观察到的CD16 +细胞百分比增加的原因。
