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年轻成年吸烟者的自由基活性

Free radical activity in young adult cigarette smokers.

作者信息

Leonard M B, Lawton K, Watson I D, MacFarlane I

机构信息

Department of Clinical Chemistry, Fazakerley Hospital, Liverpool.

出版信息

J Clin Pathol. 1995 Apr;48(4):385-7. doi: 10.1136/jcp.48.4.385.

DOI:10.1136/jcp.48.4.385
PMID:7615864
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC502563/
Abstract

Cigarette smoke is capable of generating free radicals. In this study markers of free radical activity (thiobarbituric acid reactivity, superoxide dismutase and glutathione peroxidase) were measured in young adult smoking and non-smoking volunteers. No significant differences were found in any of the free radical markers between the two groups. The number of leucocytes was elevated and a positive correlation was found between the number of leucocytes and thiobarbituric acid reactivity in the smokers. The results from this study suggest that any free radical activity generated from long term cigarette smoking in young adults is adequately scavenged.

摘要

香烟烟雾能够产生自由基。在本研究中，对年轻成年吸烟和不吸烟志愿者的自由基活性标志物（硫代巴比妥酸反应性、超氧化物歧化酶和谷胱甘肽过氧化物酶）进行了测量。两组之间的任何自由基标志物均未发现显著差异。吸烟者的白细胞数量升高，且白细胞数量与硫代巴比妥酸反应性之间存在正相关。本研究结果表明，年轻成年人长期吸烟产生的任何自由基活性均被充分清除。

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本文引用的文献

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Potential mechanism of emphysema: alpha 1-proteinase inhibitor recovered from lungs of cigarette smokers contains oxidized methionine and has decreased elastase inhibitory capacity.肺气肿的潜在机制：从吸烟者肺部回收的α1-抗胰蛋白酶含有氧化蛋氨酸，且其抑制弹性蛋白酶的能力降低。
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