Prasad A, Dunnill G S, Mortimer P S, MacGregor G A
Blood Pressure Unit, St George's Hospital Medical School, London, UK.
J Hypertens. 1995 Feb;13(2):265-8.
To determine whether there is a reduction in human forearm skin capillary density in essential hypertension.
We compared the number of capillary loops in the forearm skin of 12 patients with established, uncomplicated essential hypertension (mean blood pressure 180/109 mmHg) with that in carefully matched control subjects, using intravital capillaroscopy and fluorescein angiography.
There was a significant reduction in forearm skin capillary density in the hypertensive patients compared with the normotensive subjects. This represents a reduction by approximately 20% in capillary density. Capillary density was inversely correlated with blood pressure in the hypertensive patients alone (r = -0.4, P < 0.05) and in the whole group.
The present study demonstrates a reduction in capillary density in the forearm of patients with essential hypertension. If this rarefaction in the forearm is also present in other vascular beds, it could result in an approximately 20% increase in peripheral resistance, which might play an important additional role in determining blood pressure.
确定原发性高血压患者的人前臂皮肤毛细血管密度是否降低。
我们采用活体毛细血管镜检查和荧光素血管造影术，比较了12例确诊的、无并发症的原发性高血压患者（平均血压180/109 mmHg）与精心匹配的对照对象的前臂皮肤毛细血管袢数量。
与血压正常的对象相比，高血压患者的前臂皮肤毛细血管密度显著降低。这意味着毛细血管密度降低了约20%。仅在高血压患者中，毛细血管密度与血压呈负相关（r = -0.4，P < 0.05），在整个研究组中也是如此。
本研究表明原发性高血压患者的前臂毛细血管密度降低。如果前臂的这种稀疏现象也存在于其他血管床，可能会导致外周阻力增加约20%，这在决定血压方面可能起着重要的额外作用。
