Sciammas R, Tatsumi Y, Sperling A I, Arunan K, Bluestone J A
Department of Pathology, Ben May Institute, University of Chicago, Ill., USA.
Immunol Res. 1994;13(4):268-79. doi: 10.1007/BF02935618.
Gamma delta cells participate in pathogenic infections and autoimmune conditions, yet, almost a decade after their discovery, little is known regarding their TCR repertoire or effector functions. Unlike MHC-restricted antigen recognition employed by TCR alpha beta cells, TCR gamma delta cells can recognize whole unprocessed antigens in an MHC- independent manner. The nature of positive and negative selection used to shape the repertoire of TCR gamma delta cells is unclear, especially in the nonlymphoid tissues where these cells predominate. While TCR gamma delta cells express an activated phenotype and are present in pathological conditions, their roles in immunological protein is unknown. This review will focus on our efforts to study these issues of TCR gamma delta biology.
γδ细胞参与致病性感染和自身免疫性疾病，然而，在其被发现近十年后，关于它们的TCR库或效应功能仍知之甚少。与TCRαβ细胞采用的MHC限制性抗原识别不同，TCRγδ细胞能够以不依赖MHC的方式识别完整的未加工抗原。用于塑造TCRγδ细胞库的阳性和阴性选择的本质尚不清楚，尤其是在这些细胞占主导的非淋巴组织中。虽然TCRγδ细胞表达活化表型并存在于病理状态中，但它们在免疫蛋白中的作用尚不清楚。本综述将聚焦于我们研究TCRγδ生物学这些问题的努力。
