Loeffler D A, Connor J R, Juneau P L, Snyder B S, Kanaley L, DeMaggio A J, Nguyen H, Brickman C M, LeWitt P A
Department of Medicine, Sinai Hospital, Detroit, MI 48235, USA.
J Neurochem. 1995 Aug;65(2):710-24. doi: 10.1046/j.1471-4159.1995.65020710.x.
Oxidant-mediated damage is suspected to be involved in the pathogenesis of several neurodegenerative disorders. Iron promotes conversion of hydrogen peroxide to hydroxyl radical and, thus, may contribute to oxidant stress. We measured iron and its transport protein transferrin in caudate, putamen, globus pallidus, substantia nigra, and frontal cortex of subjects with Alzheimer's disease (n = 14) and Parkinson's disease (n = 14), and in younger adult (n = 8) and elderly (n = 8) normal controls. Although there were no differences between control groups with regard to concentrations of iron and transferrin, iron was significantly increased (p < 0.05) in Alzheimer's disease globus pallidus and frontal cortex and Parkinson's disease globus pallidus, and transferrin was significantly increased in Alzheimer's disease frontal cortex, compared with elderly controls. The transferrin/iron ratio, a measure of iron mobilization capacity, was decreased in globus pallidus and caudate in both disorders. Regional transferrin and iron concentrations were generally more highly correlated (Pearson's correlation coefficient) in elderly controls than in Alzheimer's and Parkinson's disease. The altered relationship between iron and transferrin provides further evidence that a disturbance in iron metabolism may be involved in both disorders.
氧化介导的损伤被怀疑与几种神经退行性疾病的发病机制有关。铁会促进过氧化氢转化为羟基自由基，因此可能导致氧化应激。我们测量了患有阿尔茨海默病（n = 14）和帕金森病（n = 14）的受试者以及年轻成年人（n = 8）和老年人（n = 8）正常对照的尾状核、壳核、苍白球、黑质和额叶皮质中的铁及其转运蛋白转铁蛋白。尽管对照组之间在铁和转铁蛋白浓度方面没有差异，但与老年对照组相比，阿尔茨海默病的苍白球和额叶皮质以及帕金森病的苍白球中的铁显著增加（p < 0.05），并且阿尔茨海默病额叶皮质中的转铁蛋白显著增加。转铁蛋白/铁比值是铁动员能力的指标，在这两种疾病的苍白球和尾状核中均降低。老年对照组中区域转铁蛋白和铁浓度的相关性（皮尔逊相关系数）通常比阿尔茨海默病和帕金森病中的更高。铁和转铁蛋白之间关系的改变进一步证明铁代谢紊乱可能与这两种疾病都有关。
