Griffiths P D, Crossman A R
Department of Cell and Structural Biology, Medical School, University of Manchester, UK.
Dementia. 1993 Mar-Apr;4(2):61-5. doi: 10.1159/000107298.
Post-mortem tissue was obtained from subjects with Parkinson's disease (PD), Alzheimer's disease (AD) and age-matched controls. Iron levels were measured from various sites of the basal ganglia and neocortex using atomic absorption spectrophotometry. The results indicate that iron levels are increased in the substantia nigra and the lateral segment of the globus pallidus of parkinsonian tissue. In contrast, the medial segment of the globus pallidus shows reduced iron levels in AD when compared to age-matched controls. No significant alterations of iron concentration were detected in AD in any region. These results are discussed in terms of the role of iron in the basal ganglia, mechanisms of abnormal deposition and possible neurotoxicity in PD.
尸检组织取自患有帕金森病（PD）、阿尔茨海默病（AD）的受试者以及年龄匹配的对照组。使用原子吸收分光光度法测量基底神经节和新皮层不同部位的铁含量。结果表明，帕金森病组织的黑质和苍白球外侧段铁含量增加。相比之下，与年龄匹配的对照组相比，AD患者苍白球内侧段的铁含量降低。在AD的任何区域均未检测到铁浓度的显著变化。根据铁在基底神经节中的作用、异常沉积机制以及PD中可能的神经毒性对这些结果进行了讨论。
