Wong P Y, Yue G, Yin K, Miyasaka M, Lane C L, Manning A M, Anderson D C, Sun F F
Department of Cell Biology, University of Medicine and Dentistry New Jersey, Stratford, USA.
J Pharmacol Exp Ther. 1995 Jul;274(1):475-80.
The transendothelial migration of leukocytes in many inflammatory responses is now believed to be dependent on the interaction of leukocyte and endothelial cell-derived adhesion molecules. To examine the role of intercellular adhesion molecule-1 (ICAM-1) in the development of inflammation in a rat model of colitis, we investigated the effects of antibodies to rat ICAM-1 given 24 hrs after inflammation was induced by acetic acid. Antibodies to rat ICAM-1 substantially ameliorated the inflammatory response as indicated by a reduction in gross inflammatory characteristics, tissue/body weight ratio, myeloperoxidase activity and superoxide levels. The results demonstrate that ICAM-1 plays an important role in the development of inflammatory bowel disease in rats. The use of antibodies to ICAM-1 to inhibit the adherence of leukocytes to endothelium, may be of potential therapeutic value in the treatment of inflammatory bowel disease in man.
目前认为，在许多炎症反应中白细胞的跨内皮迁移依赖于白细胞与内皮细胞衍生的黏附分子之间的相互作用。为了研究细胞间黏附分子-1（ICAM-1）在大鼠结肠炎炎症发展中的作用，我们在乙酸诱导炎症24小时后，研究了抗大鼠ICAM-1抗体的作用。抗大鼠ICAM-1抗体显著改善了炎症反应，这表现为总体炎症特征、组织/体重比、髓过氧化物酶活性和超氧化物水平的降低。结果表明，ICAM-1在大鼠炎症性肠病的发展中起重要作用。使用抗ICAM-1抗体抑制白细胞与内皮的黏附，可能对人类炎症性肠病的治疗具有潜在的治疗价值。
