Raubenheimer E J, van Heerden W F, Noffke C E
Department of Oral Pathology and Oral Biology, Medical University of Southern Africa, Medunsa.
J Oral Pathol Med. 1995 May;24(5):227-32. doi: 10.1111/j.1600-0714.1995.tb01172.x.
One hundred and eight ameloblastomas diagnosed in a rural black Africa population were analysed for clinicopathologic findings other than those classically described. One patient had a polycystic ameloblastoma adjacent to an ameloblastic fibroma. Two other polycystic ameloblastomas showed aneurysmal bone cyst formation and one mandibular tumour was diagnosed as a keratoameloblastoma. Microscopic changes resembling an adenomatoid odontogenic tumour were present in association with two unicystic ameloblastomas and a HPV18-positive verrucous lesion occurred in the lining of a cystic space of a polycystic ameloblastoma. Two ameloblastomas contained eosinophilic granules in all tumor cells and melanocytes were diffusely present in another. One case exhibited a focus of mucous cell metaplasia. Two polycystic ameloblastomas showed diffuse interstitial ossification. One mandibular tumor was diagnosed as a desmoplastic ameloblastoma and another as an odontoameloblastoma. This study demonstrated that although ameloblastomas are regarded as a fairly homogeneous group of neoplasms, detailed investigations prove clinicopathologic diversity in a significant number of lesions.
对在非洲农村黑人人群中诊断出的108例成釉细胞瘤进行了分析，以寻找除经典描述之外的临床病理特征。1例患者的多囊性成釉细胞瘤与成釉细胞纤维瘤相邻。另外2例多囊性成釉细胞瘤表现出动脉瘤样骨囊肿形成，1例下颌肿瘤被诊断为角化成釉细胞瘤。2例单囊性成釉细胞瘤出现类似腺样牙源性肿瘤的镜下改变，1例多囊性成釉细胞瘤囊腔衬里出现HPV18阳性的疣状病变。2例成釉细胞瘤的所有肿瘤细胞均含有嗜酸性颗粒，另1例成釉细胞瘤中黑色素细胞弥漫性存在。1例病例出现黏液细胞化生灶。2例多囊性成釉细胞瘤表现为弥漫性间质骨化。1例下颌肿瘤被诊断为促结缔组织增生性成釉细胞瘤，另1例为牙成釉细胞瘤。本研究表明，尽管成釉细胞瘤被认为是一组相当同质的肿瘤，但详细研究证明，大量病变存在临床病理多样性。
