Kishino M, Murakami S, Fukuda Y, Ishida T
Clinical Laboratory, Osaka University Dental Hospital, Suita, Japan.
J Oral Pathol Med. 2001 Jan;30(1):35-40. doi: 10.1034/j.1600-0714.2001.300106.x.
Desmoplastic ameloblastoma is a rare variant of ameloblastoma and only 54 cases have been previously reported in the English literature. We report ten cases of desmoplastic ameloblastoma of the jaw observed between 1972 and 1998 and discuss the pathogenesis of the tumor. Eight of the ten tumors were located in the anterior region of the jaw. Radiographically, six cases showed mixed radiolucent/radiopaque appearance with ill-defined margins and the other four cases lacked typical findings of ameloblastomas. The tumors were located mainly in the alveolar region and occupied the tooth-bearing area, without tooth resorption or impacted teeth. Histologically, the desmoplastic ameloblastomas were characterized by extensive stromal desmoplasia, and small tumor nests of odontogenic epithelium were scattered in the stroma. Oxytalan fibers stained by potassium monopersulfate-aldehyde fuchsin were demonstrated in the stroma of all desmoplastic ameloblastomas. From these findings, we presumed that the desmoplastic ameloblastomas might have developed in the periodontal membrane.
促结缔组织增生性成釉细胞瘤是成釉细胞瘤的一种罕见变异型，此前英文文献中仅报道过54例。我们报告了1972年至1998年间观察到的10例颌骨促结缔组织增生性成釉细胞瘤病例，并讨论了该肿瘤的发病机制。10例肿瘤中有8例位于颌骨前部。影像学上，6例表现为透影区与阻射区混合出现且边界不清，另外4例缺乏成釉细胞瘤的典型表现。肿瘤主要位于牙槽区，占据牙列区，无牙齿吸收或阻生牙。组织学上，促结缔组织增生性成釉细胞瘤的特征是广泛的间质结缔组织增生，牙源性上皮小肿瘤巢散在于间质中。所有促结缔组织增生性成釉细胞瘤的间质中均可见经过一硫酸钾-醛复红染色的弹力纤维。基于这些发现，我们推测促结缔组织增生性成釉细胞瘤可能起源于牙周膜。
