Sacher G A, Duffy P H
Fed Proc. 1979 Feb;38(2):184-8.
Average life spans were estimated for the male progeny from 21 of the 25 possible matings of 5 inbred mouse strains. Oxygen consumption was measured in an open system over a 48-hour interval. Resting metabolism, Mre, and average metabolism, Mav, were determined at 6-8 months of age, and at 24-34 months. Body weight, W, was determined at the time metabolism was measured. Life span, L, is negatively correlated with Mre and Mav, and positively correlated with W at both ages of measurement. This is in accord with the metabolic wear factor that had previously been established among 85 different species of mammals. A new metabolism variable, the energy partition coefficient, defined as the ratio of average to resting metabolic rate, Mav/Mre, has a parabolic relation to body weight, i.e., is maximal at an intermediate body size. The squared body weight deviation in turn has a negative correlation with life span. The correlation of L with Mav/Mre is positive, as expected, but not significant. These data suggest the existence of a longevity factor dependent on the partition of energy between the phasic metabolism of activity and the continuous maintenance metabolism.
对5个近交系小鼠品系25种可能交配组合中的21种雄性后代的平均寿命进行了估计。在开放系统中测量48小时间隔内的耗氧量。在6 - 8个月龄以及24 - 34个月龄时测定静息代谢率（Mre）和平均代谢率（Mav）。在测量代谢率时测定体重（W）。在两个测量年龄阶段，寿命（L）与Mre和Mav呈负相关，与W呈正相关。这与之前在85种不同哺乳动物中确立的代谢磨损因子一致。一个新的代谢变量，能量分配系数，定义为平均代谢率与静息代谢率之比（Mav/Mre），与体重呈抛物线关系，即在中等体型时最大。体重偏差的平方又与寿命呈负相关。正如预期的那样，L与Mav/Mre的相关性为正，但不显著。这些数据表明存在一个长寿因子，其依赖于活动的阶段性代谢和持续维持代谢之间的能量分配。
