持续热量限制可减缓代谢并减少氧化损伤，支持衰老的生活率和氧化损伤理论。
Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging.
机构信息
Division of Clinical Sciences Pennington, Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA.
Translational Research Institute for Metabolism and Diabetes, Florida Hospital and Sanford-Burnham Medical Research Institute, Orlando, FL 32804, USA.
出版信息
Cell Metab. 2018 Apr 3;27(4):805-815.e4. doi: 10.1016/j.cmet.2018.02.019. Epub 2018 Mar 22.
Calorie restriction (CR) is a dietary intervention with potential benefits for healthspan improvement and lifespan extension. In 53 (34 CR and 19 control) non-obese adults, we tested the hypothesis that energy expenditure (EE) and its endocrine mediators are reduced with a CR diet over 2 years. Approximately 15% CR was achieved over 2 years, resulting in an average 8.7 kg weight loss, whereas controls gained 1.8 kg. In the CR group, EE measured over 24 hr or during sleep was approximately 80-120 kcal/day lower than expected on the basis of weight loss, indicating sustained metabolic adaptation over 2 years. This metabolic adaptation was accompanied by significantly reduced thyroid axis activity and reactive oxygen species (F2-isoprostane) production. Findings from this 2-year CR trial in healthy, non-obese humans provide new evidence of persistent metabolic slowing accompanied by reduced oxidative stress, which supports the rate of living and oxidative damage theories of mammalian aging.
热量限制（CR）是一种饮食干预措施，具有改善健康寿命和延长寿命的潜力。在 53 名（34 名 CR 和 19 名对照）非肥胖成年人中，我们测试了这样一个假设，即 CR 饮食会在 2 年内降低能量消耗（EE）及其内分泌介质。在 2 年内实现了大约 15%的 CR，导致平均 8.7 公斤的体重减轻，而对照组体重增加了 1.8 公斤。在 CR 组中，通过 24 小时或睡眠期间测量的 EE 比基于体重减轻预期的 EE 低约 80-120 卡路里/天，这表明在 2 年内持续进行代谢适应。这种代谢适应伴随着甲状腺轴活性和活性氧（F2-异前列腺素）产生的显著降低。这项为期 2 年的 CR 试验在健康、非肥胖人群中的结果提供了新的证据，表明持续的代谢减缓伴随着氧化应激的降低，这支持了哺乳动物衰老的生活率和氧化损伤理论。
Zotero 插件