Division of Clinical Sciences Pennington, Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA.
Translational Research Institute for Metabolism and Diabetes, Florida Hospital and Sanford-Burnham Medical Research Institute, Orlando, FL 32804, USA.
Cell Metab. 2018 Apr 3;27(4):805-815.e4. doi: 10.1016/j.cmet.2018.02.019. Epub 2018 Mar 22.
Calorie restriction (CR) is a dietary intervention with potential benefits for healthspan improvement and lifespan extension. In 53 (34 CR and 19 control) non-obese adults, we tested the hypothesis that energy expenditure (EE) and its endocrine mediators are reduced with a CR diet over 2 years. Approximately 15% CR was achieved over 2 years, resulting in an average 8.7 kg weight loss, whereas controls gained 1.8 kg. In the CR group, EE measured over 24 hr or during sleep was approximately 80-120 kcal/day lower than expected on the basis of weight loss, indicating sustained metabolic adaptation over 2 years. This metabolic adaptation was accompanied by significantly reduced thyroid axis activity and reactive oxygen species (F2-isoprostane) production. Findings from this 2-year CR trial in healthy, non-obese humans provide new evidence of persistent metabolic slowing accompanied by reduced oxidative stress, which supports the rate of living and oxidative damage theories of mammalian aging.
热量限制（CR）是一种饮食干预措施，具有改善健康寿命和延长寿命的潜力。在 53 名（34 名 CR 和 19 名对照）非肥胖成年人中，我们测试了这样一个假设，即 CR 饮食会在 2 年内降低能量消耗（EE）及其内分泌介质。在 2 年内实现了大约 15%的 CR，导致平均 8.7 公斤的体重减轻，而对照组体重增加了 1.8 公斤。在 CR 组中，通过 24 小时或睡眠期间测量的 EE 比基于体重减轻预期的 EE 低约 80-120 卡路里/天，这表明在 2 年内持续进行代谢适应。这种代谢适应伴随着甲状腺轴活性和活性氧（F2-异前列腺素）产生的显著降低。这项为期 2 年的 CR 试验在健康、非肥胖人群中的结果提供了新的证据，表明持续的代谢减缓伴随着氧化应激的降低，这支持了哺乳动物衰老的生活率和氧化损伤理论。
