Brody J S, Vaccaro C
Fed Proc. 1979 Feb;38(2):215-23.
This paper details some of the interstitial events associated with the formation of alveoli during early postnatal life and the physiological consequences of alterations in this process. Formation of alveoli coincides with differentiation of dormant interstitial fibroblasts into myofibroblasts within new alveolar buds and lipid-filled fibroblasts at the base of these buds. The myofibroblasts appear to be involved in synthesis and secretion of elastin and perhaps other connective tissue elements. Glycosaminoglycans identified with ruthenium red or tannic acid appear in the extracellular matrix of the buds. The role of the lipid-filled fibroblast is uncertain. Since lung size increases at a greater rate than airway size during the early postnatal period, conditions that stimulate or depress postnatal lung alveolarization influence relative airflow rates. Highland natives have larger than normal lungs and low relative maximal expiratory airflow. Hamsters whose growth has been blunted by protein malnutrition have small lungs but large relative maximal expiratory airflow. These results illustrate the physiological importance of dysanaptic lung growth.
本文详细阐述了出生后早期肺泡形成过程中一些相关的间质事件，以及该过程改变所产生的生理后果。肺泡的形成与新肺泡芽内休眠的间质成纤维细胞分化为肌成纤维细胞以及这些芽基部充满脂质的成纤维细胞同时发生。肌成纤维细胞似乎参与弹性蛋白以及可能其他结缔组织成分的合成与分泌。用钌红或鞣酸鉴定的糖胺聚糖出现在芽的细胞外基质中。充满脂质的成纤维细胞的作用尚不确定。由于出生后早期肺大小的增长速度快于气道大小，刺激或抑制出生后肺肺泡化的情况会影响相对气流速率。高原地区的本地人肺部比正常人大，但相对最大呼气气流较低。因蛋白质营养不良而生长受阻的仓鼠肺部较小，但相对最大呼气气流较大。这些结果说明了肺发育不匀称生长的生理重要性。
