Hsu A C, Folami A O, Bain J, Rance C P
Fertil Steril. 1979 Feb;31(2):173-7. doi: 10.1016/s0015-0282(16)43818-5.
Analysis of semen from 16 patients treated with cyclophosphamide for nephrotic syndrome showed azoospermia in three and oligospermia in seven. Analysis was normal in the other six. Prolonged treatment, particularly with larger total dosage, was associated with a higher incidence of gonadal dysfunction. Recovery was not evident at follow-up, 2 years and 9 months to 9 years and 1 month after cessation of the therapy. Limitation of treatment with cyclophosphamide to 8 weeks/course (2.5 mg/kg/day) minimizes this side effect without greatly increasing the rate of relapse of the nephrotic syndrome in the first 2 years after therapy.
对16例因肾病综合征接受环磷酰胺治疗的患者的精液分析显示，3例无精子症，7例少精子症。其他6例分析结果正常。长期治疗，尤其是总剂量较大时，与性腺功能障碍的发生率较高有关。在治疗停止后2年9个月至9年1个月的随访中，恢复情况不明显。将环磷酰胺治疗限制在8周/疗程（2.5毫克/千克/天）可将这种副作用降至最低，且不会在治疗后的头2年大幅增加肾病综合征的复发率。
