Watson A R, Taylor J, Rance C P, Bain J
Fertil Steril. 1986 Aug;46(2):331-3. doi: 10.1016/s0015-0282(16)49537-3.
The gonadal function of 18 women who were treated for childhood nephrotic syndrome at a mean age of 10.7 years with cyclophosphamide (mean dosage, 28 gm; mean duration of therapy, 354 days) was evaluated at a mean of 14.5 years after treatment by means of detailed questionnaires. Menstrual patterns were normal in all except two, who were still receiving intermittent prednisone therapy. Eight healthy children had been born to five mothers. Compared with males, there is little current evidence of gonadal toxicity in this patient group. Further follow-up is required to determine whether these women will undergo premature menopause.
对18名曾在平均年龄10.7岁时接受环磷酰胺治疗（平均剂量28克；平均治疗持续时间354天）的儿童肾病综合征女性患者，在治疗后平均14.5岁时通过详细问卷评估其性腺功能。除两名仍在接受间歇性泼尼松治疗的患者外，其他患者的月经模式均正常。5名母亲已生育8名健康儿童。与男性相比，目前该患者组几乎没有性腺毒性的证据。需要进一步随访以确定这些女性是否会过早绝经。
