给药途径对孕酮代谢的影响。
Influence of route of administration on progesterone metabolism.
作者信息
de Lignieres B, Dennerstein L, Backstrom T
机构信息
Département d'endocrinologie et Médecine de la Reproduction, Hopital Necker, Paris, France.
出版信息
Maturitas. 1995 Apr;21(3):251-7. doi: 10.1016/0378-5122(94)00882-8.
PMID:7616875
Abstract
While inducing similar progesterone levels, the ratio of 5 alpha- and 5 beta-pregnanolone/progesterone plasma concentrations has been dramatically increased after oral as opposed to vaginal administration, in a cross-over study. The known psychotropic effects of 5 alpha- and 5 beta-pregnanolone lead to different indications and precautions for oral and vaginal administration of progesterone.
摘要
在一项交叉研究中，虽然口服和阴道给药诱导的孕酮水平相似，但口服给药后血浆中5α-和5β-孕烷醇酮/孕酮的浓度比与阴道给药相比显著增加。5α-和5β-孕烷醇酮已知的精神otropic作用导致孕酮口服和阴道给药有不同的适应症和注意事项。
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