Buhr-Schinner H, Laier-Groeneveld G, Criée C P
Evangelisches Krankenhaus Lenglern, Abteilung Beatmungsmedizin und Schlaf, Universität Göttingen.
Med Klin (Munich). 1995 Apr;90(1 Suppl 1):49-51.
Fully informed patients were willing to start with IPPV.
Twenty-three patients with amyothropic lateral sclerosis (ALS) were treated with noninvasive intermittent mechanical ventilation (7 women, 16 men, mean age 59 years). The major symptoms were dyspnoe, heavy sleep disruption resulting in severely reduced quality of life.
Their symptoms improved. The blood gases normalized during spontaneous breathing. They remained stable, despite a rapid decrease in respiratory force. Thirteen patients died, 6 during an acute event, 4 during bronchopulmonary infection and 3 stopped therapy, when they were fully ventilator dependent.
We conclude that respiratory symptoms and quality of life can be improved by home intermittent mechanical ventilation. Indication should therefore be made earlier.
充分知情的患者愿意开始接受间歇正压通气（IPPV）治疗。
23例肌萎缩侧索硬化症（ALS）患者接受了无创间歇性机械通气治疗（7名女性，16名男性，平均年龄59岁）。主要症状为呼吸困难、严重的睡眠中断导致生活质量严重下降。
他们的症状有所改善。自主呼吸时血气恢复正常。尽管呼吸力量迅速下降，但他们的病情保持稳定。13例患者死亡，6例死于急性事件，4例死于支气管肺部感染，3例在完全依赖呼吸机时停止治疗。
我们得出结论，家庭间歇性机械通气可改善呼吸症状和生活质量。因此，应更早地做出治疗指征判断。
