Myśliwski A, Sosnowska D, Bigda J
Medical University of Gdańsk, Department of Histology and Immunology, Poland.
Neoplasma. 1996;43(5):311-3.
The growth of transplanted Bomirski melanoma in hamsters is accompanied by the decrease of natural killer cytotoxic activity and the formation of metastases. The excision of primary tumors was carried out to examine what was the effect of the growing tumor and its metastases on the host's NK activity. It was found that the excision of primary tumor caused increased NK cytotoxic activity in comparison to that of nonoperated animals although it was still lower than that of healthy hamsters. It is concluded that both, a growing tumor and metastases, exert suppressive effects on NK activity and those effects add up. The pattern of metastases in operated animals was different to that observed in nontreated hamsters.
移植到仓鼠体内的博米尔斯基黑色素瘤的生长伴随着自然杀伤细胞细胞毒性活性的降低和转移灶的形成。切除原发性肿瘤以研究生长中的肿瘤及其转移灶对宿主自然杀伤细胞活性有何影响。结果发现，与未手术的动物相比，切除原发性肿瘤后自然杀伤细胞的细胞毒性活性有所增加，尽管仍低于健康仓鼠。结论是，生长中的肿瘤和转移灶都会对自然杀伤细胞活性产生抑制作用，且这些作用会叠加。手术动物的转移模式与未治疗仓鼠中观察到的不同。
