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Natural killer sensitivity of tumor cells isolated from primary and metastatic lesions of four Bomirski melanoma variants.

作者信息

Bigda J, Myśliwski A, Sosnowska D, Romanowski P, Bomirski A

机构信息

Medical School, Department of Histology, Gdańsk, Poland.

出版信息

Clin Exp Metastasis. 1991 Jan-Feb;9(1):57-65. doi: 10.1007/BF01831710.

DOI:10.1007/BF01831710
PMID:2015718
Abstract

Natural killer (NK) sensitivity of melanoma cells isolated from primary and metastatic lesions of four Bomirski melanoma variants was compared. The hamster melanomas differed in their growth rate and metastatic pattern. We found that during tumor growth of all the variants tested, NK sensitivity of melanoma cells at the metastasis formation stage was significantly lower in both primary and metastatic tumors than in cells isolated from primary tumors at transplantation. In the case of Ma, Ab and Ab-455, NK sensitivity of primary tumor cells was higher than that of the cells isolated from metastatic deposits. These data obtained from a spontaneous metastasis tumor model argue for the role of NK cells in preventing metastatic spread of Bomirski melanomas studied.

摘要

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引用本文的文献

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Arch Immunol Ther Exp (Warsz). 2007 Jul-Aug;55(4):267-79. doi: 10.1007/s00005-007-0031-9. Epub 2007 Jul 23.

本文引用的文献

1
Tumour cells in metastatic deposits with altered sensitivity to natural killer cells.转移灶中的肿瘤细胞对自然杀伤细胞的敏感性发生改变。
Int J Cancer. 1981 Aug 15;28(2):191-8. doi: 10.1002/ijc.2910280213.
2
The role of natural killer cells in the control of tumor growth and metastasis.自然杀伤细胞在控制肿瘤生长和转移中的作用。
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Mechanisms of tumor progression.肿瘤进展机制。
Cancer Res. 1986 May;46(5):2203-7.
4
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7
Interferon-gamma treatment of B16 melanoma cells: opposing effects for non-adaptive and adaptive immune defense and its reflection by metastatic spread.γ干扰素对B16黑色素瘤细胞的治疗：对非适应性和适应性免疫防御的相反作用及其通过转移扩散的反映。
Int J Cancer. 1988 Feb 15;41(2):256-66. doi: 10.1002/ijc.2910410217.
8
Interferon gamma induces lung colonization by intravenously inoculated B16 melanoma cells in parallel with enhanced expression of class I major histocompatibility complex antigens.γ干扰素可诱导静脉接种的B16黑色素瘤细胞在肺部定植，同时增强I类主要组织相容性复合体抗原的表达。
Proc Natl Acad Sci U S A. 1987 May;84(10):3405-9. doi: 10.1073/pnas.84.10.3405.
9
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Cancer Surv. 1988;7(4):597-629.
10
Interaction of tumor cells and immune system in the metastatic process.肿瘤细胞与免疫系统在转移过程中的相互作用。
Biochem Cell Biol. 1988 Jun;66(6):617-25. doi: 10.1139/o88-071.