Tedeschi G, Bertolino A, Righini A, Campbell G, Raman R, Duyn J H, Moonen C T, Alger J R, Di Chiro G
Neuroimaging Branch, NINDS, NIH, Bethesda, MD 20892, USA.
Neurology. 1995 Jul;45(7):1384-91. doi: 10.1212/wnl.45.7.1384.
Proton magnetic resonance spectroscopy (1H-MRS) is evolving from single-volume localized acquisitions to multiple-volume acquisitions using magnetic resonance spectroscopic imaging (1H-MRSI). The normal regional patterns of 1H-MRSI-detectable metabolite signal intensities have yet to be established. We studied 13 healthy young adults with a multiple-section 1H-MRSI technique. The metabolite signals measured were N-acetylaspartate (NA), choline-containing compounds (CHO), creatine-phosphocreatine (CRE), and lactate. Ten neuroanatomic regions (nine bilateral) were identified in gray matter, white matter, and basal nuclei. Analysis of the data led to the following conclusions: (1) NA and CHO signals from centrum semiovale (CSO) can be used as a normalizing factor to reduce intersubject variability due to external causes; (2) in normal human brain, there is no left versus right asymmetry in the regions studied; (3) statistically significant patterns of signal distribution of NA, CHO, and CRE can be identified in normal human brain; and (4) CSO-normalized metabolite signal intensities and metabolite ratios complement each other for the detection of significant regional differences.
质子磁共振波谱（1H-MRS）正从单容积局部采集发展为使用磁共振波谱成像（1H-MRSI）的多容积采集。1H-MRSI可检测到的代谢物信号强度的正常区域模式尚未确立。我们使用多层面1H-MRSI技术研究了13名健康的年轻成年人。所测量的代谢物信号为N-乙酰天门冬氨酸（NA）、含胆碱化合物（CHO）、肌酸-磷酸肌酸（CRE）和乳酸。在灰质、白质和基底核中确定了10个神经解剖区域（9对双侧区域）。数据分析得出以下结论：（1）半卵圆中心（CSO）的NA和CHO信号可作为归一化因子，以减少外部因素导致的个体间变异性；（2）在正常人类大脑中，所研究的区域不存在左右不对称性；（3）在正常人类大脑中可识别出NA、CHO和CRE信号分布的统计学显著模式；（4）CSO归一化代谢物信号强度和代谢物比率在检测显著区域差异方面相互补充。
