Esfahani N, Bednar I, Qureshi G A, Södersten P
Department of Clinical Neuroscience and General Medicine, Karolinska Institute, Huddinge, Sweden.
Pharmacol Biochem Behav. 1995 May;51(1):9-12. doi: 10.1016/0091-3057(94)00400-d.
Ingestive behavior was activated in male rats by intraoral infusion of a 1-M solution of sucrose. Injection of cholecystokinin octapeptide (CCK-8; 1.6 or 5.0 micrograms) inhibited ingestion of the sucrose solution and increased the concentration of 5-hydroxytryptamine (5-HT) in the paraventricular hypothalamic nuclei. The inhibitory effect of the low, but not the high, dose of CCK-8 was attenuated by depleting 5-HT in the brain with p-chlorophenylalanine (PCPA; 100 mg/kg for 3 days). Treatment with 5-hydroxytryptophan (20 mg/kg) increased the concentration of 5-HT in the brain of rats pretreated with either NaCl or PCPA and enhanced the inhibitory effect of CCK-8 on ingestive behavior in the PCPA-, but not NaCl-, treated rats. 5-HT may play a role in the mechanism of action of CCK-8 but additional factors must be involved.
通过向雄性大鼠口腔内注入1-M的蔗糖溶液来激活其摄食行为。注射八肽胆囊收缩素（CCK-8；1.6或5.0微克）会抑制蔗糖溶液的摄取，并增加下丘脑室旁核中5-羟色胺（5-HT）的浓度。用对氯苯丙氨酸（PCPA；100毫克/千克，持续3天）耗尽大脑中的5-HT后，低剂量而非高剂量的CCK-8的抑制作用会减弱。用5-羟色氨酸（20毫克/千克）处理可增加用NaCl或PCPA预处理的大鼠大脑中5-HT的浓度，并增强CCK-8对PCPA处理而非NaCl处理的大鼠摄食行为的抑制作用。5-HT可能在CCK-8的作用机制中发挥作用，但必定涉及其他因素。
